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Dr. D'Souza's primary research interest is in infectious disease, risk behaviors, and translational epidemiology. She leads a research program focused on the epidemiology of viral infections and their health outcomes. Her works focuses on HPV and related cancers, risk triage and risk communication. In addition Dr. D'Souza is a PI of the MACS-WIHS Combined Cohort Study, a large multisite study of HIV in the U.S.