About this Course
최근 조회 6,696

100% 온라인

지금 바로 시작해 나만의 일정에 따라 학습을 진행하세요.

유동적 마감일

일정에 따라 마감일을 재설정합니다.

완료하는 데 약 18시간 필요

권장: 14.5 hours of videos...

영어

자막: 영어

100% 온라인

지금 바로 시작해 나만의 일정에 따라 학습을 진행하세요.

유동적 마감일

일정에 따라 마감일을 재설정합니다.

완료하는 데 약 18시간 필요

권장: 14.5 hours of videos...

영어

자막: 영어

강의 계획 - 이 강좌에서 배울 내용

1
완료하는 데 1시간 필요

Welcome

Welcome to the course!

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3 videos (Total 19 min), 3 readings
3개의 동영상
Description of Parts7m
Introduction: Why Electrons?8m
3개의 읽기 자료
Welcome from Professor Jensen10m
About the Instructor10m
Concept Check Questions: Why Electrons?10m
2
완료하는 데 3시간 필요

Currents, Coils, Knobs and Names: Basic anatomy of the electron microscope

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9 videos (Total 94 min), 8 readings
9개의 동영상
Electron Guns18m
EM Lenses
The Column26m
Sample Chamber14m
Energy Filters7m
Detectors11m
Vacuum Systems9m
Summary and Safety5m
8개의 읽기 자료
Concept Check Questions: Electron Guns10m
Concept Check Questions: Electron Lenses10m
Concept Check Questions: The Column10m
Concept Check Questions: The Sample Chamber10m
Concept Check Questions: Energy Filters10m
Concept Check Questions: Electron Detectors10m
Concept Check Questions: Vacuum Systems10m
Concept Check Questions: Summary and Safety10m
3
완료하는 데 3시간 필요

Fourier Transforms and Reciprocal Space for Beginners

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7 videos (Total 134 min), 6 readings
7개의 동영상
1-D Sine Waves and their Sums32m
1-D Reciprocal Space20m
2-D Waves and Images19m
2-D Transforms and Filters32m
3-D Waves and Transforms13m
Convolution and Cross-Correlation15m
6개의 읽기 자료
Concept Check Questions: 1-D Sine Waves and Their Sums10m
Concept Check Questions: 1-D Reciprocal Space10m
Concept Check Questions: 2-D Waves and Images10m
Concept Check Questions: 2-D Transforms and Filters10m
Concept Check Questions: 3-D Waves and Transforms10m
Concept Check Questions: Convolution and Cross-correlation10m
4
완료하는 데 4시간 필요

Image Formation

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7 videos (Total 164 min), 6 readings
7개의 동영상
Amplitude and Phase Contrast30m
Wave Propagation and Phase Shifts30m
The Contrast Transfer Function33m
Defocus and its Effects21m
Envelopes16m
CTF Correction31m
6개의 읽기 자료
Concept Check Questions: Amplitude and Phase Contrast10m
Concept Check Questions: Wave Propagation and Phase Shifts10m
Concept Check Questions: The Contrast Transfer Function10m
Concept Check Questions: Defocus and its Effects10m
Concept Check Questions: Envelopes10m
Concept Check Questions: CTF Correction10m
5
완료하는 데 2시간 필요

Fundamental Challenges in Biological EM

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6 videos (Total 96 min), 5 readings
6개의 동영상
Sample Prep - Room Temperature Methods20m
Sample Prep Methods Involving Freezing27m
Sample Prep Grids11m
3-D Reconstruction11m
Dose Limitations22m
5개의 읽기 자료
Concept Check Questions: Sample Prep - Room Temperature Methods10m
Concept Check Questions: Sample Prep - Methods Involving Freezing10m
Concept Check Questions: Sample Prep - Grids10m
Concept Check Questions: 3-D Reconstruction10m
Concept Check Questions: Dose Limitations10m
6
완료하는 데 4시간 필요

Single Particle Analysis

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5 videos (Total 159 min), 6 readings
5개의 동영상
Data collection (imaging)21m
Reconstruction basics31m
Reconstruction: additional topics44m
Interpretation and limitations38m
6개의 읽기 자료
Concept check questions: Introduction to single particle analysis10m
Concept Check Questions: Special sample prep issues10m
Concept Check Questions: Data collection (imaging)10m
Concept Check Questions: Reconstruction basics10m
Concept Check Questions: Reconstruction - additional topics10m
Concept Check Questions: Interpretation and limitations10m
7
완료하는 데 3시간 필요

Tomography

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5 videos (Total 131 min), 5 readings
5개의 동영상
Tomography Data Collection and Reconstruction40m
Tomography Identifying Objects of Interest24m
Tomography Limitations29m
Tomography Parameters and Handedness12m
5개의 읽기 자료
Concept Check Questions: Introduction: Tomography10m
Concept Check Questions: Tomography Data Collection and Reconstruction10m
Concept Check Questions: Identifying Objects in Tomograms10m
Concept Check Questions: Tomography Limitations10m
Concept Check Questions: Tomography Parameters and Handedness10m
8
완료하는 데 2시간 필요

2-D Crystallography

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5 videos (Total 55 min), 4 readings
5개의 동영상
FT of a 2-D Crystal24m
2-D Crystallography Data Collection and Reconstruction17m
Helical Tubes3m
Farewell2m
4개의 읽기 자료
Concept Check Questions: Introduction: 2-D Crystallography and Sample Prep10m
Concept Check Questions: Fourier Transform of a 2-D Crystal10m
Concept Check Questions: Data Collection and Reconstruction10m
Concept Check Questions: Helical Tubes10m
4.9
42개의 리뷰Chevron Right

Getting started in cryo-EM의 최상위 리뷰

대학: LRFeb 19th 2018

Great course. I thought it was presented in a very informative way and i learned a lot about cryo-EM. In fact, it made me want to learn more about it. Thank you.

대학: ALJul 20th 2016

An excellent introduction to the topic, explaining from the basics to the detail of things. Useful and recommended to anyone in structural biology.

강사

Avatar

Grant J. Jensen

Professor of Biophysics and Biology; Investigator, Howard Hughes Medical Institute
Biology and Biological Engineering

캘리포니아 공과대학 정보

Caltech is a world-renowned science and engineering research and education institution, where extraordinary faculty and students seek answers to complex questions, discover new knowledge, lead innovation, and transform our future. Caltech's mission is to expand human knowledge and benefit society through research integrated with education. We investigate the most challenging, fundamental problems in science and technology in a singularly collegial, interdisciplinary atmosphere, while educating outstanding students to become creative members of society....

자주 묻는 질문

  • 강좌에 등록하면 바로 모든 비디오, 테스트 및 프로그래밍 과제(해당하는 경우)에 접근할 수 있습니다. 상호 첨삭 과제는 이 세션이 시작된 경우에만 제출하고 검토할 수 있습니다. 강좌를 구매하지 않고 살펴보기만 하면 특정 과제에 접근하지 못할 수 있습니다.

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