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Welcome to the Evidence-based Toxicology (EBT) course. In medicine and healthcare, evidence-based medicine has revolutionized the way that information is evaluated transparently and objectively. Over the past ten years, a movement in North America and Europe has attempted to translate this revolution to the field of toxicology.
The Center for Alternatives to Animal Testing (CAAT) within the department of Environmental Health and Engineering at the Johns Hopkins Bloomberg School of Public Health hosts the first chair for EBT and the secretariat for the EBT Collaboration on both sides of the Atlantic. Based on the Cochrane Collaboration in Evidence-based Medicine, the EBT Collaboration was established at the CAAT to foster the development of a process for quality assurance of new toxicity tests for the assessment of safety in humans and the environment.
Regulatory safety sciences have undergone remarkably little change in the past fifty years. At the same time, our knowledge in the life sciences is doubling about every seven years. Systematic review and related evidence-based approaches are beginning to be adapted by regulatory agencies like the Environment Protection Agency (EPA), the European Food Safety Authority (EFSA), and the US National Toxicology Program. They provide transparent, objective, and consistent tools to identify, select, appraise, and extract evidence across studies. 
This course will showcase these emerging efforts and address opportunities and challenges to the expanded use of these tools within toxicology.

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지금 바로 시작해 나만의 일정에 따라 학습을 진행하세요.

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일정에 따라 마감일을 재설정합니다.

초급 단계

완료하는 데 약 17시간 필요

영어

자막: 영어

공유 가능한 수료증

완료 시 수료증 획득

100% 온라인

지금 바로 시작해 나만의 일정에 따라 학습을 진행하세요.

유동적 마감일

일정에 따라 마감일을 재설정합니다.

초급 단계

완료하는 데 약 17시간 필요

영어

자막: 영어

강의 계획 - 이 강좌에서 배울 내용

주

1

주 1

완료하는 데 2시간 필요

Introduction & Shortcomings of Current Approaches

This module introduces you to the course, outlines the shortcomings of current toxicity testing approaches, and shows how EBT can help to overcome these shortcomings.

완료하는 데 2시간 필요

9개 동영상 (총 66분), 3 개의 읽기 자료, 1 개의 테스트

9개의 동영상

Welcome3m

Introduction to the Course14m

Introduction5m

Shortcoming No. 1: Narrative Reviews7m

Shortcoming No. 2: Bias in Reviews7m

Shortcoming No. 3: Evidence Writing4m

Shortcoming No. 4: External Validity10m

Shortcoming No. 5: Assessing New Methods5m

Shortcoming No. 6: Inadequate Reporting7m

3개의 읽기 자료

Letter to Learners10m

Course Learning Objectives10m

Supporting reading10m

1개 연습문제

Practice Quiz 18m

주

2

주 2

완료하는 데 3시간 필요

History and Causation

This module explains how evidence-based toxicology originated and describes the driving forces for the initiative. In the second lesson, you will learn how to distinguish between correlation and causation as well as the main problems with drawing conclusions on the basis of correlations. The Bradford Hill criteria are introduced, along with examples for each criterion. You will also learn about mechanistic toxicology and mechanistic validation.

완료하는 데 3시간 필요

11개 동영상 (총 138분), 2 개의 읽기 자료, 1 개의 테스트

11개의 동영상

Welcome to Module 21m

Personal First Exposures to Evidence-Based Medicine21m

The Start of EBT16m

The First Conference 2007 to the Start of the EBT Collaboration 201114m

The Evidence-Based Toxicology Collaboration (EBTC)13m

Introduction Causation vs. Correlation18m

The Hill Principles of Epidemiology and their Relation to Toxicology16m

The Problem of Causation in Toxicology16m

Biomarker Concept in Mechanistic Toxicology4m

Mechanistic Validation4m

The Future of Causation in Complex Systems9m

2개의 읽기 자료

Supporting reading10m

1개 연습문제

Practice Quiz 210m

주

3

주 3

완료하는 데 3시간 필요

Systematic Review and Meta-Analysis

This module shows how to perform systematic reviews and meta-analyses. You will learn the history of both methods and will receive step-by-step instructions on how to perform systematic reviews and meta-analyses using examples from the research activities of the instructors.

완료하는 데 3시간 필요

8개 동영상 (총 101분), 2 개의 읽기 자료, 2 개의 테스트

8개의 동영상

Welcome to Module 33m

Systematic Reviews: Definition and Principles26m

Systematic Reviews - Protocol Development15m

Systematic Reviews - Protocol Development (Part 2)19m

History5m

Meta-analysis Guidelines7m

Meta-analysis Protocol, Part 110m

Meta-analysis Protocol, Part 212m

2개의 읽기 자료

Supporting reading10m

2개 연습문제

Practice Quiz 36m

Mid-course exam30m

주

4

주 4

완료하는 데 2시간 필요

Risk of Bias & Application to Test Methods Comparison

This module teaches you about possible biases that can be introduced at different stages of research. Each bias is explained with examples, including solutions for overcoming those biases. The second lesson covers systematic review of the zebrafish embryotoxicity test as a case study conducted by the Evidence-based Toxicology Collaboration (EBTC). You will go through all of the steps of the systematic review again to imprint the knowledge from module 3, but this systematic review will be related to a toxicological method.

완료하는 데 2시간 필요

8개 동영상 (총 94분), 2 개의 읽기 자료, 1 개의 테스트

8개의 동영상

Welcome to Module 43m

Introduction to Risk of Bias Concept in Critical Appraisal of Studies26m

Examples for Risk of Bias Tools 1: Cochrane Collboration4m

Examples for Risk of Bias Tools 2: SYRCLE's RoB Tool5m

Examples of Risk of Bias Tools 3: National Institute for Environmental Health Sciences (NIEHS) - OHAT12m

Quality Assessment in Evidence-Based Toxicology7m

Evidence-Based Toxicology (EBT) and Evidence-Based Toxicology Collaboration (EBTC)11m

Zebrafish Systematic Review22m

2개의 읽기 자료

Supporting reading10m

1개 연습문제

Practice Quiz 410m

주

5

주 5

완료하는 데 3시간 필요

Quality Assurance, Good Practices, and Validation

Quality control is a very important aspect of not only modern toxicology but the entirety of life sciences. The first lesson in this module demonstrates the importance of performing quality control on your experiments. The second lesson is connected with the first one because validation of an alternative method requires highly standardized protocols and quality control at each step. This lesson teaches you different aspects of alternatives methods validation, how to perform classical validation, its pitfalls, and strategies to overcome them.

완료하는 데 3시간 필요

10개 동영상 (총 140분), 2 개의 읽기 자료, 1 개의 테스트

10개의 동영상

Welcome to Module 52m

The Concepts of Quality Assurance (QA) and Good Practice (GP)14m

Good Practice22m

Quality Assurance12m

Importance of GP and QA in EBT5m

The Evolution of Validation of Alternative Methods29m

The Traditional Validation Process26m

Example of a Validation Study: Skin Irritation9m

Developments in the Validation Area6m

Validation and Tox-21c/EBT11m

2개의 읽기 자료

Supporting reading10m

1개 연습문제

Practice Quiz 56m

주

6

주 6

완료하는 데 2시간 필요

Biometrical Tools & Future Perspectives

Evidence-based toxicology requires some knowledge of bioinformatics. The first lesson in the module teaches you some biostatistical tools you can apply when analyzing predectivity, specificity, and sensitivity of a method. You will also learn how to identify biases in a study with the help of bioinformatics. Evidence-based principles can be applied to every question you might have, even to which pizza to order tonight. You will learn the difference between eminence-based vs. evidence-based approaches. You will learn what is driving the lack of reproducibility and how evidence-based approaches should help to overcome the reproducibility crisis in science, which is explained with examples of experimental design, wrong models, poor quality of the cell cultures, etc.

완료하는 데 2시간 필요

8개 동영상 (총 98분), 1 개의 읽기 자료, 2 개의 테스트

8개의 동영상

Welcome to Module 64m

Why We Need Biometry/Statistics in Evidence-Based Toxicology9m

Statistics and Bioinformatics Applied in Evidence-Based Approaches I11m

Statistics and Bioinformatics Applied in Evidence-Based Approaches II18m

Risk and Bias and Its Impact on Evidence-Based Approaches12m

Evidence-Based Is a More Rigorous Scientific Approach to Anything4m

The Reproducibility Crisis in Science25m

Where Is Evidence-Based Toxicology (EBT) and What Are The Next Steps?11m

1개의 읽기 자료

Supporting reading10m

2개 연습문제

Practice quiz 64m

Final exam30m

주

7

주 7

완료하는 데 2시간 필요

Summative Assessment - Systematic Review Assignment

The final week of the course is devoted to completing the Systematic Review Assignment. You will use SysRev to review at least 20 abstracts, apply inclusion and exclusion criteria, render decisions, and resolve conflicts with other reviewers.

완료하는 데 2시간 필요

1 개의 읽기 자료

1개의 읽기 자료

Systematic Review Assignment Instructions1시간 30분

1개 연습문제

Systematic Review Assignment Results30m

자주 묻는 질문

When will I have access to the lectures and assignments?
Access to lectures and assignments depends on your type of enrollment. If you take a course in audit mode, you will be able to see most course materials for free. To access graded assignments and to earn a Certificate, you will need to purchase the Certificate experience, during or after your audit. If you don't see the audit option:

The course may not offer an audit option. You can try a Free Trial instead, or apply for Financial Aid.

The course may offer 'Full Course, No Certificate' instead. This option lets you see all course materials, submit required assessments, and get a final grade. This also means that you will not be able to purchase a Certificate experience.
What will I get if I purchase the Certificate?

When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.
What is the refund policy?

You will be eligible for a full refund until two weeks after your payment date, or (for courses that have just launched) until two weeks after the first session of the course begins, whichever is later. You cannot receive a refund once you’ve earned a Course Certificate, even if you complete the course within the two-week refund period. See our full refund policy.
Is financial aid available?

Yes, Coursera provides financial aid to learners who cannot afford the fee. Apply for it by clicking on the Financial Aid link beneath the "Enroll" button on the left. You’ll be prompted to complete an application and will be notified if you are approved. Learn more.

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Evidence-based Toxicology