About this Course
10,764

다음의 2/7개 강좌

100% 온라인

지금 바로 시작해 나만의 일정에 따라 학습을 진행하세요.

탄력적인 마감일

일정에 따라 마감일을 재설정합니다.

초급 단계

완료하는 데 약 15시간 필요

영어

자막: 영어, 중국어 (간체자)

귀하가 습득할 기술

AlgorithmsPython ProgrammingWhole Genome SequencingDynamic Programming

다음의 2/7개 강좌

100% 온라인

지금 바로 시작해 나만의 일정에 따라 학습을 진행하세요.

탄력적인 마감일

일정에 따라 마감일을 재설정합니다.

초급 단계

완료하는 데 약 15시간 필요

영어

자막: 영어, 중국어 (간체자)

강의 계획 - 이 강좌에서 배울 내용

1
완료하는 데 4시간 필요

Week 1: Introduction to Genome Sequencing

<p>Welcome to class!</p><p>This course will focus on two questions at the forefront of modern computational biology, along with the algorithmic approaches we will use to solve them in parentheses:</p><ol><li>Weeks 1-2: How Do We Assemble Genomes? (<i>Graph Algorithms</i>)</li><li>How Do We Sequence Antibiotics? (<i>Brute Force Algorithms</i>)</li></ol><p>Each of the two chapters of content in the class is accompanied by a Bioinformatics Cartoon created by talented San Diego artist Randall Christopher and serving as a chapter header in the Specialization's bestselling <a href="http://bioinformaticsalgorithms.com" target="_blank">print companion</a>. You can find the first chapter's cartoon at the bottom of this message. What does a time machine trip to 1735, a stack of newspapers, a jigsaw puzzle, and a giant ant invading a riverside city have to do with putting together a genome? Start learning today to find out!</p><p><img src="https://d396qusza40orc.cloudfront.net/bioinformatics%2Fimages%2Fchapter4_final_lr.jpg" title="Image: https://d396qusza40orc.cloudfront.net/bioinformatics%2Fimages%2Fchapter4_final_lr.jpg" width="528"></p>...
8 videos (Total 36 min), 2 readings, 3 quizzes
8개의 동영상
FIELD TRIP!4m
What Is Genome Sequencing?6m
Exploding Newspapers4m
The String Reconstruction Problem3m
String Reconstruction as a Hamiltonian Path Problem3m
String Reconstruction as an Eulerian Path Problem5m
Similar Problems with Different Fates 3m
2개의 읽기 자료
Course Details10m
Week 1 FAQs (Optional)
1개 연습문제
Week 1 Quiz15m
2
완료하는 데 3시간 필요

Week 2: Applying Euler's Theorem to Assemble Genomes

<p>Welcome to Week 2 of class!</p> <p>This week in class, we will see how a 300 year-old mathematical theorem will help us assemble a genome from millions of tiny pieces of DNA.</p>...
5 videos (Total 28 min), 1 reading, 3 quizzes
5개의 동영상
Euler's Theorem 6m
Assembling Read-Pairs 8m
De Bruijn Graphs Face Harsh Realities of Assembly 4m
Returning to Konigsberg 1m
1개의 읽기 자료
Week 2 FAQs (Optional)
1개 연습문제
Week 2 Quiz15m
3
완료하는 데 4시간 필요

Week 3: Sequencing Antibiotics

<p>Welcome to Week 3 of class!</p> <p>This week, we begin a new chapter, titled "How Do We Sequence Antibiotics?" &nbsp;In this chapter, we will learn&nbsp;how to determine the amino acid sequences making up antibiotics using brute force algorithms.</p> <p>Below is this week's Bioinformatics Cartoon.</p> <p><img src="https://d396qusza40orc.cloudfront.net/bioinformatics%2Fimages%2Fchapter2_final.jpg" title="Image: https://d396qusza40orc.cloudfront.net/bioinformatics%2Fimages%2Fchapter2_final.jpg" width="528"></p>...
5 videos (Total 27 min), 1 reading, 3 quizzes
5개의 동영상
How Do Bacteria Make Antibiotics? 8m
Sequencing Antibiotics by Shattering Them into Pieces 4m
A Brute Force Algorithm for Cyclopeptide Sequencing 3m
Cyclopeptide Sequencing with Branch and Bound 6m
1개의 읽기 자료
Week 3 FAQs (Optional)
1개 연습문제
Week 3 Quiz15m
4
완료하는 데 3시간 필요

Week 4: From Ideal to Real Spectra for Antibiotics Sequencing

<p>Welcome to Week 4 of class!</p> <p>Last week, we discussed how to sequence an antibiotic peptide from an ideal spectrum. This week, we will see how to develop more sophisticated algorithms for antibiotic peptide sequencing that are able to handle spectra with many false and missing masses.</p>...
4 videos (Total 18 min), 1 reading, 3 quizzes
4개의 동영상
From 20 to More than 100 Amino Acids 2m
The Spectral Convolution Saves the Day 6m
The Truth About Spectra 2m
1개의 읽기 자료
Week 4 FAQs (Optional)
1개 연습문제
Week 4 Quiz15m
4.8
39개의 리뷰Chevron Right

33%

이 강좌를 수료한 후 새로운 경력 시작하기

25%

이 강좌를 통해 확실한 경력상 이점 얻기

최상위 리뷰

대학: SVJan 10th 2017

Great course to explore a bit of Bioinformatics for those with no background in Bioinformatics. I love the way the content has been provided, its interactivity increases the interest in the course.

대학: MPDec 8th 2017

I like the real-world tasks, especially the assembly on the final exam. Some of the programming tasks, such as the antibiotic noisy spectrum assembly, are challenging (which is good).

강사

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Pavel Pevzner

Professor
Department of Computer Science and Engineering
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Phillip Compeau

Visiting Researcher
Department of Computer Science & Engineering

캘리포니아 샌디에고 대학교 정보

UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 10 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom—life is their laboratory....

생물 정보학 전문 분야 정보

Join Us in a Top 50 MOOC of All Time! How do we sequence and compare genomes? How do we identify the genetic basis for disease? How do we construct an evolutionary Tree of Life for all species on Earth? When you complete this Specialization, you will learn how to answer many questions in modern biology that have become inseparable from the computational approaches used to solve them. You will also obtain a toolkit of existing software resources built on these computational approaches and that are used by thousands of biologists every day in one of the fastest growing fields in science. Although this Specialization centers on computational topics, you do not need to know how to program in order to complete it. If you are interested in programming, we feature an "Honors Track" (called "hacker track" in previous runs of the course). The Honors Track allows you to implement the bioinformatics algorithms that you will encounter along the way in dozens of automatically graded coding challenges. By completing the Honors Track, you will be a bioinformatics software professional! Learn more about the Bioinformatics Specialization (including why we are wearing these crazy outfits) by watching our introductory video. You can purchase the Specialization's print companion, Bioinformatics Algorithms: An Active Learning Approach, from the textbook website. Our first course, "Finding Hidden Messages in DNA", was named a top-50 MOOC of all time by Class Central!...
생물 정보학

자주 묻는 질문

  • 강좌에 등록하면 바로 모든 비디오, 테스트 및 프로그래밍 과제(해당하는 경우)에 접근할 수 있습니다. 상호 첨삭 과제는 이 세션이 시작된 경우에만 제출하고 검토할 수 있습니다. 강좌를 구매하지 않고 살펴보기만 하면 특정 과제에 접근하지 못할 수 있습니다.

  • 강좌를 등록하면 전문 분야의 모든 강좌에 접근할 수 있고 강좌를 완료하면 수료증을 취득할 수 있습니다. 전자 수료증이 성취도 페이지에 추가되며 해당 페이지에서 수료증을 인쇄하거나 LinkedIn 프로필에 수료증을 추가할 수 있습니다. 강좌 내용만 읽고 살펴보려면 해당 강좌를 무료로 청강할 수 있습니다.

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