About this Course
최근 조회 3,486

100% 온라인

지금 바로 시작해 나만의 일정에 따라 학습을 진행하세요.

유동적 마감일

일정에 따라 마감일을 재설정합니다.

중급 단계

완료하는 데 약 26시간 필요

권장: 6 weeks of study, 3-6 hours per week...

영어

자막: 영어

100% 온라인

지금 바로 시작해 나만의 일정에 따라 학습을 진행하세요.

유동적 마감일

일정에 따라 마감일을 재설정합니다.

중급 단계

완료하는 데 약 26시간 필요

권장: 6 weeks of study, 3-6 hours per week...

영어

자막: 영어

강의 계획 - 이 강좌에서 배울 내용

1
완료하는 데 75시간 필요

Module 1

This model will give you a broad introduction to the Toxicology 21st century (Tox21c) field and familiarize you with the main document, which summarize the main ideas and principles of Tox21c.

...
10 videos (Total 121 min), 3 readings, 1 quiz
10개의 동영상
Center for Alternatives to Animal Testing4m
Toxicology of the Fifteenth to Twentieth Centuries15m
Toxicology for the Twenty-First Century15m
Historical Perspective17m
The First Report: Toxicity Testing for Assessment of Environmental Agents11m
The Second Report: Toxicity Testing in the 21st Century: A Vision and A Strategy Vision and Its Components22m
The Second Report: Toxicity Testing in the 21st Century: A vision and A Strategy Implementation13m
3개의 읽기 자료
useful links20m
supporting reading material10m
Supporting reading material10m
1개 연습문제
Module 1 Quiz
2
완료하는 데 5시간 필요

Module 2

This module will discuss how ToxCast and Tox21 technologies can be used in practice. The US EPA Endocrine Disruptor Screening Program will be discussed in detail and we will demonstrate how the ToxCast platform replaced in vivo tiered approaches in EDSP and, thus, acelerate the process of . In the second lesson of this module, the development of in silico models for toxicity testing will be discussed.

...
10 videos (Total 119 min), 4 readings, 2 quizzes
10개의 동영상
ER Bioactivity Model16m
US EPA Endocrine Disruptor Screening Program (EDSP)17m
Modeling of Hazard and Organ Manifestation11m
Building a Signature for Vascular Disruption10m
Testing the Vascular Disruption Signature8m
Virtual Tissue Model: Vascular Development12m
Functional Vascular Development Assays16m
4개의 읽기 자료
Supporting Reading Material10m
Useful links10m
Supporting Reading Material10m
Useful links10m
1개 연습문제
Module 2 Quiz8m
3
완료하는 데 3시간 필요

Module 3

This module will familiarize you with the Human Toxome Project run by Johns Hopkins University in collaboration with several university, industry, and research agencies. Omics technologies, their advantages and disadvantages, as well as concepts of Adverse Outcome Pathways (AOP) and Pathways of Toxicity (PoT) will be discussed.

...
11 videos (Total 126 min), 2 readings, 1 quiz
11개의 동영상
Concept and Tool Devlopment11m
Progress7m
Conclusions and Prospectives8m
Introduction - What Is a Pathway of Toxicity, and Why Do We Need Them?6m
Omics Technologies and High-Throughput Data11m
Interpreting Omics Data11m
PoT Examples and Conclusions15m
Pathways of Toxicity and Adverse Outcome Pathways (AOPs)13m
2개의 읽기 자료
Supporting reading materials10m
Supporting reading material10m
1개 연습문제
Module 3 Quiz8m
4
완료하는 데 4시간 필요

Module 4

The first lesson in this module will explain the concept of read-across, why it is important for regulatory risk assessment, and how it can be implemented by industry in response to REACH legislation. The organotypic cultures lesson will teach you about existing in vitro cell-based models starting from simple monolayer cultures of cell lines and ending with complex combined organ-on-a-chip and human-on-a-chip approaches.

...
15 videos (Total 148 min), 3 readings, 2 quizzes
15개의 동영상
Building, Evaluating, and Using AOPs in Safety Decisions6m
Online Tools Available to Everyone, Including an Online AOP Course4m
Welcome to Module 42m
Introduction to Read-Across18m
Good Read-Across Practice21m
Supporting Read-Across with Biological Data12m
Creating a Database of Toxicity12m
Creating an Automated Tool for Read-Across9m
Paradigm Shift in Toxicology7m
2D In Vitro Cell Culture8m
3D In Vitro Cell Cultures8m
Organ-on-a-Chip11m
3개의 읽기 자료
Supporting reading material10m
Supporting reading material10m
Useful links10m
2개 연습문제
Module 4 Quiz8m
Mid-term exam44m
완료하는 데 1시간 필요

Module 5

This module will teach you the role of miRNA and epigenetics in toxicology and environmental health.

...
6 videos (Total 41 min), 1 reading, 1 quiz
6개의 동영상
MicroRNA: Biogenesis and Functions11m
Role of MicroRNA in Development6m
MicroRNA in Toxicology9m
1개의 읽기 자료
Supporting reading material10m
1개 연습문제
Module 5 Quiz8m
4.5
5개의 리뷰Chevron Right

Toxicology 21: Scientific Applications의 최상위 리뷰

대학: SMay 4th 2018

Very nicely designed course. The instructors offer an excellent and easy to understand overview of a range of promising Tox21 tools and approaches using good examples and illustrations.

대학: NKDec 27th 2018

A very well-taught course with lots of useful information. I highly recommend it.

강사

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Lena Smirnova

Research Associate
Center for Alternatives to Animal Testing
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Thomas Hartung

Professor
Environmental Health and Engineering

존스홉킨스대학교 정보

The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world....

자주 묻는 질문

  • 강좌에 등록하면 바로 모든 비디오, 테스트 및 프로그래밍 과제(해당하는 경우)에 접근할 수 있습니다. 상호 첨삭 과제는 이 세션이 시작된 경우에만 제출하고 검토할 수 있습니다. 강좌를 구매하지 않고 살펴보기만 하면 특정 과제에 접근하지 못할 수 있습니다.

  • 수료증을 구매하면 성적 평가 과제를 포함한 모든 강좌 자료에 접근할 수 있습니다. 강좌를 완료하면 전자 수료증이 성취도 페이지에 추가되며, 해당 페이지에서 수료증을 인쇄하거나 LinkedIn 프로필에 수료증을 추가할 수 있습니다. 강좌 콘텐츠만 읽고 살펴보려면 해당 강좌를 무료로 청강할 수 있습니다.

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