About this 전문분야
최근 조회 9,406

100% 온라인 강좌

지금 바로 시작해 나만의 일정에 따라 학습을 진행하세요.

유동적 일정

유연한 마감을 설정하고 유지 관리합니다.

중급 단계

완료하는 데 약 7개월 필요

매주 5시간 권장

영어

자막: 영어, 중국어 (간체자)

귀하가 습득할 기술

BiologyMolecular BiologyDynamical SystemsMatlab

100% 온라인 강좌

지금 바로 시작해 나만의 일정에 따라 학습을 진행하세요.

유동적 일정

유연한 마감을 설정하고 유지 관리합니다.

중급 단계

완료하는 데 약 7개월 필요

매주 5시간 권장

영어

자막: 영어, 중국어 (간체자)

How the 전문분야 Works

강좌 수강

Coursera 전문 분야는 기술을 완벽하게 습득하는 데 도움이 되는 일련의 강좌입니다. 시작하려면 전문 분야에 직접 등록하거나 강좌를 둘러보고 원하는 강좌를 선택하세요. 하나의 전문 분야에 속하는 강좌에 등록하면 해당 전문 분야 전체에 자동으로 등록됩니다. 단 하나의 강좌만 수료해도 됩니다. — 학습을 일시 중지하거나 언제든 구독을 종료할 수 있습니다. 학습자 대시보드를 방문하여 강좌 등록 상태와 진도를 추적해 보세요.

실습 프로젝트

모든 전문 분야에는 실습 프로젝트가 포함되어 있습니다. 전문 분야를 완료하고 수료증을 받으려면 프로젝트를 성공적으로 마쳐야 합니다. 전문 분야에 별도의 실습 프로젝트 강좌가 포함되어 있는 경우 각 강좌를 완료해야 프로젝트를 시작할 수 있습니다.

수료증 취득

모든 강좌를 마치고 실습 프로젝트를 완료하면 취업할 때나 전문가 네트워크에 진입할 때 제시할 수 있는 수료증을 취득할 수 있습니다.

how it works

이 전문분야에는 6개의 강좌가 있습니다.

강좌1

Introduction to Systems Biology

4.3
310개의 평가
60개의 리뷰

This course will introduce the student to contemporary Systems Biology focused on mammalian cells, their constituents and their functions. Biology is moving from molecular to modular. As our knowledge of our genome and gene expression deepens and we develop lists of molecules (proteins, lipids, ions) involved in cellular processes, we need to understand how these molecules interact with each other to form modules that act as discrete functional systems. These systems underlie core subcellular processes such as signal transduction, transcription, motility and electrical excitability. In turn these processes come together to exhibit cellular behaviors such as secretion, proliferation and action potentials. What are the properties of such subcellular and cellular systems? What are the mechanisms by which emergent behaviors of systems arise? What types of experiments inform systems-level thinking? Why do we need computation and simulations to understand these systems? The course will develop multiple lines of reasoning to answer the questions listed above. Two major reasoning threads are: the design, execution and interpretation of multivariable experiments that produce large data sets; quantitative reasoning, models and simulations. Examples will be discussed to demonstrate “how” cell- level functions arise and “why” mechanistic knowledge allows us to predict cellular behaviors leading to disease states and drug responses.

...
강좌2

Experimental Methods in Systems Biology

4.6
171개의 평가
27개의 리뷰

Learn about the technologies underlying experimentation used in systems biology, with particular focus on RNA sequencing, mass spec-based proteomics, flow/mass cytometry and live-cell imaging. A key driver of the systems biology field is the technology allowing us to delve deeper and wider into how cells respond to experimental perturbations. This in turns allows us to build more detailed quantitative models of cellular function, which can give important insight into applications ranging from biotechnology to human disease. This course gives a broad overview of a variety of current experimental techniques used in modern systems biology, with focus on obtaining the quantitative data needed for computational modeling purposes in downstream analyses. We dive deeply into four technologies in particular, mRNA sequencing, mass spectrometry-based proteomics, flow/mass cytometry, and live-cell imaging. These techniques are often used in systems biology and range from genome-wide coverage to single molecule coverage, millions of cells to single cells, and single time points to frequently sampled time courses. We present not only the theoretical background upon which these technologies work, but also enter real wet lab environments to provide instruction on how these techniques are performed in practice, and how resultant data are analyzed for quality and content.

...
강좌3

Network Analysis in Systems Biology

4.5
124개의 평가
16개의 리뷰

An introduction to data integration and statistical methods used in contemporary Systems Biology, Bioinformatics and Systems Pharmacology research. The course covers methods to process raw data from genome-wide mRNA expression studies (microarrays and RNA-seq) including data normalization, differential expression, clustering, enrichment analysis and network construction. The course contains practical tutorials for using tools and setting up pipelines, but it also covers the mathematics behind the methods applied within the tools. The course is mostly appropriate for beginning graduate students and advanced undergraduates majoring in fields such as biology, math, physics, chemistry, computer science, biomedical and electrical engineering. The course should be useful for researchers who encounter large datasets in their own research. The course presents software tools developed by the Ma’ayan Laboratory (http://labs.icahn.mssm.edu/maayanlab/) from the Icahn School of Medicine at Mount Sinai, but also other freely available data analysis and visualization tools. The ultimate aim of the course is to enable participants to utilize the methods presented in this course for analyzing their own data for their own projects. For those participants that do not work in the field, the course introduces the current research challenges faced in the field of computational systems biology.

...
강좌4

Dynamical Modeling Methods for Systems Biology

4.7
134개의 평가
26개의 리뷰

An introduction to dynamical modeling techniques used in contemporary Systems Biology research. We take a case-based approach to teach contemporary mathematical modeling techniques. The course is appropriate for advanced undergraduates and beginning graduate students. Lectures provide biological background and describe the development of both classical mathematical models and more recent representations of biological processes. The course will be useful for students who plan to use experimental techniques as their approach in the laboratory and employ computational modeling as a tool to draw deeper understanding of experiments. The course should also be valuable as an introductory overview for students planning to conduct original research in modeling biological systems. This course focuses on dynamical modeling techniques used in Systems Biology research. These techniques are based on biological mechanisms, and simulations with these models generate predictions that can subsequently be tested experimentally. These testable predictions frequently provide novel insight into biological processes. The approaches taught here can be grouped into the following categories: 1) ordinary differential equation-based models, 2) partial differential equation-based models, and 3) stochastic models.

...

강사

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Eric Sobie, PhD

Associate Professor
Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York (SBCNY)
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Susana Neves, PhD

Assistant Professor
Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York (SBCNY)
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Ravi Iyengar, PhD

Dorothy H. and Lewis Rosenstiel Professor
Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York (SBCNY)
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Marc Birtwistle, PhD

Assistant Professor
Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York (SBCNY)
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Avi Ma’ayan, PhD

Director, Mount Sinai Center for Bioinformatics
Professor, Department of Pharmacological Sciences
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Iman Tavassoly, MD, PhD

Systems Biology Center New York (SBCNY)

마운트사이나이 아이칸 의과대학 정보

The Icahn School of Medicine at Mount Sinai, in New York City is a leader in medical and scientific training and education, biomedical research and patient care....

자주 묻는 질문

  • 네! 시작하려면 관심 있는 강좌 카드를 클릭하여 등록합니다. 강좌를 등록하고 완료하면 공유할 수 있는 인증서를 얻거나 강좌를 청강하여 강좌 자료를 무료로 볼 수 있습니다. 전문 분야 과정에 있는 강좌에 등록하면, 전체 전문 분야에 등록하게 됩니다. 학습자 대시보드에서 진행 사항을 추적할 수 있습니다.

  • 이 강좌는 100% 온라인으로 진행되므로 강의실에 직접 참석할 필요가 없습니다. 웹 또는 모바일 장치를 통해 언제 어디서든 강의, 읽기 자료, 과제에 접근할 수 있습니다.

  • 이 전문 분야는 대학 학점을 제공하지 않지만, 일부 대학에서 선택적으로 전문 분야 인증서를 학점으로 인정할 수도 있습니다. 자세한 내용은 해당 기관에 문의하세요.

  • Time to completion can vary based on your schedule, but most learners are able to complete the Specialization in 12 months.

  • Some college-level cell and molecular biology, basic statistics and calculus.

  • The first (Introduction to Systems Biology) and last course (Integrated Analysis in Systems Biology) should be taken in sequence. There is flexibility in taking the middle three courses. These courses may be taken in any sequence, but are best taken in the order listed.

  • Coursera courses and certificates don't carry university credit, though some universities may choose to accept Specialization Certificates for credit. Check with your institution to learn more.

  • You will be able to design and implement systems biology methods to solve biomedical problems. The systems biology specialization covers all areas of systems biology in biomedical sciences.

  • You will have access to Matlab provided by MathWorks whenever it is needed. Other programs and softwares used in the courses are freely available.

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