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Finding Mutations in DNA and Proteins (Bioinformatics VI)(으)로 돌아가기

캘리포니아 샌디에고 대학교의 Finding Mutations in DNA and Proteins (Bioinformatics VI) 학습자 리뷰 및 피드백

4.7
별점
56개의 평가

강좌 소개

In previous courses in the Specialization, we have discussed how to sequence and compare genomes. This course will cover advanced topics in finding mutations lurking within DNA and proteins. In the first half of the course, we would like to ask how an individual's genome differs from the "reference genome" of the species. Our goal is to take small fragments of DNA from the individual and "map" them to the reference genome. We will see that the combinatorial pattern matching algorithms solving this problem are elegant and extremely efficient, requiring a surprisingly small amount of runtime and memory. In the second half of the course, we will learn how to identify the function of a protein even if it has been bombarded by so many mutations compared to similar proteins with known functions that it has become barely recognizable. This is the case, for example, in HIV studies, since the virus often mutates so quickly that researchers can struggle to study it. The approach we will use is based on a powerful machine learning tool called a hidden Markov model. Finally, you will learn how to apply popular bioinformatics software tools applying hidden Markov models to compare a protein against a related family of proteins....

최상위 리뷰

TK

2016년 6월 28일

One of the best specialization on Coursera. Highly recommended for anyone who wants to apply his/her programming skills to fascinating real-world problems.

EJ

2021년 7월 31일

Great course! It opened my mind on the capabilities of algorithms beyond its intended purpose.

필터링 기준:

Finding Mutations in DNA and Proteins (Bioinformatics VI)의 13개 리뷰 중 1~13

교육 기관: Samuel C

•

2018년 9월 16일

Really enjoyed this course. It was great to get to build on work from previous courses.

교육 기관: Jason M

•

2020년 6월 23일

Really loved learning about suffix trees/arrays, BWT, Pattern matching, HMMs!

교육 기관: Mohamed A

•

2017년 8월 14일

Good course. I did this course after the course "Algorithms for DNA Sequencing" of Ben Langmead. Since Ben Langmead was excellent in his explanations, my expectations were the same for this course but I felt that it is not as good as Ben Langmead course maybe because there are no practical videos about programming ideas.

교육 기관: Tamas K

•

2016년 6월 29일

One of the best specialization on Coursera. Highly recommended for anyone who wants to apply his/her programming skills to fascinating real-world problems.

교육 기관: Edgardo P F J

•

2021년 7월 31일

Great course! It opened my mind on the capabilities of algorithms beyond its intended purpose.

교육 기관: Ramiz G

•

2020년 4월 14일

It was probably my favorite in this specialization (at least, out of first six).

교육 기관: Sakshar C

•

2020년 7월 1일

The contents were so well organized and helpful to develop a proper insight

교육 기관: Zack X

•

2019년 7월 21일

In depth and comprehensive coverage of the topics in genetic data analysis.

교육 기관: Arsham M N

•

2022년 4월 1일

I​t was the greatest course I've ever attended.

교육 기관: Mare B

•

2020년 5월 16일

Very good.

교육 기관: Thomas L

•

2017년 7월 17일

Very interesting material. The only reason I marked this course as 4 stars instead of 5 stars is by comparison to the other courses in this specialization. This course does not have the online textbook which means that the student needs to work through the lecture videos very closely in order to be able to solve the programming assignments.

교육 기관: Thomas G

•

2018년 12월 20일

Much more difficult than 1-5 or 7!

교육 기관: Weidong X

•

2017년 2월 27일

good

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