About this Course
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지금 바로 시작해 나만의 일정에 따라 학습을 진행하세요.

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자막: 영어, 스페인어

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CancerMolecular BiologyCancer EpigeneticsDna Methylation

100% 온라인

지금 바로 시작해 나만의 일정에 따라 학습을 진행하세요.

유동적 마감일

일정에 따라 마감일을 재설정합니다.


자막: 영어, 스페인어

강의 계획 - 이 강좌에서 배울 내용

완료하는 데 2시간 필요

Week 1 - Introduction to Epigenetic Control

An introduction to and definition of epigenetic control of gene expression, and its importance in normal development. We will learn what chromatin is, and how its composition and packaging can alter gene expression. We’ll also discuss the best-characterised epigenetic modification, DNA methylation, and how it is not only implicated in regulating gene expression, but also in maintaining genome stability.

7 videos (Total 65 min), 5 readings, 1 quiz
7개의 동영상
1.3 Chromatin and the nucleosome6m
1.4 Chromatin compaction - heterochromatin versus euchromatin9m
1.5 DNA methylation at CpG islands11m
1.6 DNA methylation at intergenic regions and repetitive elements15m
5개의 읽기 자료
Course syllabus10m
Teaching team10m
Start of course survey10m
Assessment and grading policy10m
Week 1 and 2 resources10m
1개 연습문제
Week 1 quiz - contributes 8% towards your final grade20m
완료하는 데 2시간 필요

Week 2 - Epigenetic Modifications and Organisation of the Nucleus

We’ll discuss the molecular mechanisms for regulating gene expression in some detail, from how the DNA is packaged at a local level, right up to how the chromatin is positioned within the nucleus. We’ll learn about the chromatin modifications implicated in gene silencing and activation, the role of non-coding RNA, and higher order chromatin structures. This week will provide you with a good understanding of the basic mechanisms that will help you understand the processes we discuss throughout the rest of the course.

9 videos (Total 90 min), 1 reading, 1 quiz
9개의 동영상
2.4 Histone variants8m
2.5 Noncoding RNAs - microRNAs6m
2.6 Noncoding RNAs - piRNAs9m
2.7 Noncoding RNAs - long noncoding RNAs introduction10m
2.8 Long noncoding RNAs Xist and HOTAIR7m
2.9 3D organisation of the nucleus and summary of epigenetic marks17m
1개의 읽기 자료
Week 1 and 2 resources10m
1개 연습문제
Week 2 quiz - contributes 8% towards your final grade20m
완료하는 데 3시간 필요

Week 3 - Dosage Compensation

X chromosome inactivation is a really well-characterised epigenetic process that is now used as a model system to study epigenetic processes that are relevant more broadly. This is because it uses many epigenetic mechanisms, at many levels, to achieve really stable silencing of a whole chromosome. We’ll learn about this process and how it occurs in a mouse in great detail, which will greatly add to the mechanistic understanding gained in week two. We will then briefly discuss alternate mechanisms for dosage compensation that occur in other organisms.

12 videos (Total 113 min), 1 reading, 1 quiz
12개의 동영상
3.4 Control of Xist expression by pluripotency factors6m
3.5 Stages of X inactivation - choice of which X to inactivate9m
3.6 Stages of X inactivation - initiation and spreading of silencing11m
3.7 Stages of X inactivation - establishment of silencing6m
3.8 Stages of X inactivation - maintenance of silencing e.g. Dnmt18m
3.9 Stages of X inactivation - maintenance of silencing e.g. Smchd18m
3.10 X chromosome inactivation summary10m
3.11 Dosage compensation in flies and worms, compared with mammals8m
3.12 Lessons from the fly - position effect variegation and screening for epigenetic modifiers10m
1개의 읽기 자료
Week 3 resources (including required readings)10m
1개 연습문제
Week 3 quiz - contributes 12% towards your final grade30m
완료하는 데 2시간 필요

Week 4 - Genomic Imprinting and Epigenetic Reprogramming

We’ll learn about the two important periods during development for the erasure and resetting of the epigenome. There are two well-characterised features that are treated differently during epigenetic reprogramming; imprinted genes and repeats. We’ll learn about mechanisms for genomic imprinting, and study three examples in more depth.

6 videos (Total 68 min), 1 reading, 1 quiz
6개의 동영상
4.4 Kcnq1 and H19/Igf2 ICR mechanisms of action and Beckwith Weidemann syndrome17m
4.5 Snrpn ICR mechanism, Prader Willi and Angelman syndromes13m
4.6 Summary of epigenetic reprogramming and imprinting6m
1개의 읽기 자료
Week 4 resources (including required reading)10m
1개 연습문제
Week 4 quiz - contributes 12% towards your final grade30m
113개의 리뷰Chevron Right


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Epigenetic Control of Gene Expression의 최상위 리뷰

대학: MMOct 2nd 2018

This was an excellent course. All the material was well presented and the explanation of the sometimes complex subject matter was clear and understandable. Thank you for an great learning experience.

대학: DSAug 25th 2018

This is an excellent course that introduces you to fundamental knowledge of several hot topics in the field of epigenetics. Dr. Blewitt herself studies X inactivation, and I learned so much!



Dr. Marnie Blewitt

Head, Molecular Medicine Laboratory
Walter and Eliza Hall Institute of Medical Research

멜버른 대학교 정보

The University of Melbourne is an internationally recognised research intensive University with a strong tradition of excellence in teaching, research, and community engagement. Established in 1853, it is Australia's second oldest University....

자주 묻는 질문

  • 강좌에 등록하면 바로 모든 비디오, 테스트 및 프로그래밍 과제(해당하는 경우)에 접근할 수 있습니다. 상호 첨삭 과제는 이 세션이 시작된 경우에만 제출하고 검토할 수 있습니다. 강좌를 구매하지 않고 살펴보기만 하면 특정 과제에 접근하지 못할 수 있습니다.

  • 수료증을 구매하면 성적 평가 과제를 포함한 모든 강좌 자료에 접근할 수 있습니다. 강좌를 완료하면 전자 수료증이 성취도 페이지에 추가되며, 해당 페이지에서 수료증을 인쇄하거나 LinkedIn 프로필에 수료증을 추가할 수 있습니다. 강좌 콘텐츠만 읽고 살펴보려면 해당 강좌를 무료로 청강할 수 있습니다.

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